مرکز تحقیقات غدد و متابولیسم | اخبار مرکز

مرکز تحقیقات غدد و متابولیسم | اخبار مرکز
سایت دانشگاه | 13 بهمن 1404
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مرکز تحقیقات غدد و متابولیسم

دانشگاه علوم پزشکی تهران

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The effects of Abemaciclib on cell cycle and apoptosis regulation in anaplastic thyroid cancer cells
thyroid cancer

The effects of Abemaciclib on cell cycle and apoptosis regulation in anaplastic thyroid cancer cells

Anaplastic thyroid cancer (ATC) is an aggressive subtype of thyroid cancer, accounting for 1 to 2% of all cases. Deregulations of cell cycle regulatory genes including cyclins, cyclin-dependent kinases (CDKs), and endogenous inhibitors of CDKs (CKIs) are hallmarks of cancer cells and hence, studies indicate the inhibition of CDK4/6 kinases and cell cycle progression as potent therapeutic strategies. In this study, we investigated the anti-tumor activity of Abemaciclib, a CDK4 and CDK6 inhibitor, in ATC cell lines

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