IWGDF guidance
Adoption of IWGDF guidance on prevention and management of foot problems in diabetes for local use in Iran by ADAPTE methodology: a step toward best practice
Adoption of international working group on the diabetic foot (IWGDF) guidance on prevention and management of foot problems in patients with diabetes was the study aim.
Ramadan Fasting
Nutritional Education Needs in Relation to Ramadan Fasting and Its Complications in Tehran, Iran
Ramadan fasting is associated with some lifestyle changes. A lack of nutritional needs knowledge or the improper performance of fasting, particularly in relation to time, type and amount of food intake, can cause disorders such as indigestion
Junk food
Junk food consumption and psychological distress in children and adolescents: a systematic review and meta-analysis
Available evidence indicates that junk foods, defined as unhealthy foods with high-calorie and low-nutrient value, negatively affect mental and metabolic health of children. This study aimed to conduct a meta-analysis to clarify the association between junk food consumption and psychological distress in children and adolescents
microbiota dysbiosis
The critical role of gut microbiota dysbiosis in skeletal muscle wasting: a systematic review
Skeletal muscle wasting is affected by the gut microbiota dysbiosis through multiple pathways, including inflammatory process, defected immune system, and anabolic resistance. We aimed to systematically review the studies investigating the gut microbiota composition in sarcopenic and cachexic humans and animals
thyroid cancer
The effects of Abemaciclib on cell cycle and apoptosis regulation in anaplastic thyroid cancer cells
Anaplastic thyroid cancer (ATC) is an aggressive subtype of thyroid cancer, accounting for 1 to 2% of all cases. Deregulations of cell cycle regulatory genes including cyclins, cyclin-dependent kinases (CDKs), and endogenous inhibitors of CDKs (CKIs) are hallmarks of cancer cells and hence, studies indicate the inhibition of CDK4/6 kinases and cell cycle progression as potent therapeutic strategies. In this study, we investigated the anti-tumor activity of Abemaciclib, a CDK4 and CDK6 inhibitor, in ATC cell lines
thyroid cancer
Illuminating the role of lncRNAs ROR and MALAT1 in cancer stemness state of anaplastic thyroid cancer: An exploratory study
Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans that accounts for a considerable rate of cancer-associated mortality
diabetes
An application of CART algorithms for detection of an association between VDR polymor-phisms and reduced bone density in individuals with type 2 diabetes: a population-based cross-sectional study
An important part of preventing major common diseases is identifying genetic factors that contribute to their occurrence. For the first time in our knowledge, we investigated the association between polymorphisms of five vitamin D receptor (VDR) genes (ApaI, BsmI, FokI, EcoRV, and TaqI) and low bone density/osteopenia/osteoporosis in individuals with type 2 diabetes using classification and regression tree (CART) algorithms.
triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates
[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies
Regarding the important role of the urease enzyme as a virulence factor in urease-positive microorganisms in this study, new series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized
Footwear and offloading
Footwear and offloading interventions to prevent and heal diabetic foot ulcers: Adapted IWGDF guidance
Foot ulcer is one of the greatest complications of diabetes. If there is no effective pressure reduction in the ulcer, healing may be delayed
Psychotic
Psychotic Disorder as the First Manifestation of Addison Disease: A Case Report
Addison disease (AD) is a relatively uncommon endocrine disease resulting from adrenal insufficiency